Dynamic stability of sequential stimulus representations in adapting neuronal networks.

ABSTRACT: The ability to acquire and maintain appropriate representations of time-varying, sequential stimulus events is a fundamental feature of neocortical circuits and a necessary first step toward more specialized information processing. The dynamical properties of such representations depend on the current state of the circuit, which is determined primarily by the ongoing, internally generated activity, setting the ground state from which input-specific transformations emerge. Here, we begin by demonstrating that timing-dependent synaptic plasticity mechanisms have an important role to play in the active maintenance of an ongoing dynamics characterized by asynchronous and irregular firing, closely resembling cortical activity in vivo. Incoming stimuli, acting as perturbations of the local balan

SUBMITTER: Duarte RC 

PROVIDER: S-EPMC4205815 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature