Sea foam as a source of fungal inoculum for the isolation of biologically active natural products.

ABSTRACT: Due to a rate increase in the resistance of microbial pathogens to currently used antibiotics, there is a need in society for the discovery of novel antimicrobials. Historically, fungi are a proven source for antimicrobial compounds. The main goals of this study were to investigate the fungal diversity associated with sea foam collected around the coast of Prince Edward Island and the utility of this resource for the production of antimicrobial natural products. Obtained isolates were identified using ITS and nLSU rDNA sequences, fermented on four media, extracted and fractions enriched in secondary metabolites were screened for antimicrobial activity. The majority of the isolates obtained were ascomycetes, consisting of four recognized marine taxa along with other ubiquitous genera and ma

SUBMITTER: Overy DP 

PROVIDER: S-EPMC4205912 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature