Parkinson disease and smoking revisited: ease of quitting is an early sign of the disease.

ABSTRACT:

Objective

To assess whether being able to quit smoking is an early marker of Parkinson disease (PD) onset rather than tobacco being "neuroprotective," we analyzed information about ease of quitting and nicotine substitute use.

Methods

For this case-control study, we identified 1,808 patients with PD diagnosed between 1996 and 2009 from Danish registries, matched 1,876 population controls on sex and year of birth, and collected lifestyle information. We estimated odds ratios and 95% confidence intervals with logistic regression adjusting for matching factors and confounders.

Results

Fewer patients with PD than controls ever established a smoking habit. Among former smokers, those with greater difficulty quitting or using nicotine substitutes were less likely to develop

SUBMITTER: Ritz B 

PROVIDER: S-EPMC4206154 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature