Gold-catalyzed 1,3-transposition of ynones.

ABSTRACT: An efficient, regioselective gold-catalyzed 1,3-transposition reaction of ynones and diynones has been developed. It was found that stereoelectronic (interrupted conjugation) and electronic (extended conjugation) factors could efficiently govern the regioselectivity of this thermodynamically controlled transformation. The produced conjugated diynones were efficiently transformed into diverse alkyne-substituted five- and six-membered heterocycles.

SUBMITTER: Kazem Shiroodi R 

PROVIDER: S-EPMC4206192 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature