MAPK14/p38α-dependent modulation of glucose metabolism affects ROS levels and autophagy during starvation.

ABSTRACT: Increased glycolytic flux is a common feature of many cancer cells, which have adapted their metabolism to maximize glucose incorporation and catabolism to generate ATP and substrates for biosynthetic reactions. Indeed, glycolysis allows a rapid production of ATP and provides metabolic intermediates required for cancer cells growth. Moreover, it makes cancer cells less sensitive to fluctuations of oxygen tension, a condition usually occurring in a newly established tumor environment. Here, we provide evidence for a dual role of MAPK14 in driving a rearrangement of glucose metabolism that contributes to limiting reactive oxygen species (ROS) production and autophagy activation in condition of nutrient deprivation. We demonstrate that MAPK14 is phosphoactivated during nutrient deprivation an

SUBMITTER: Desideri E 

PROVIDER: S-EPMC4206541 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature