Saphenous vein graft failure after coronary artery bypass surgery: insights from PREVENT IV.

ABSTRACT:

Background

Coronary artery bypass grafting success is limited by vein graft failure (VGF). Understanding the factors associated with VGF may improve patient outcomes.

Methods and results

We examined 1828 participants in the Project of Ex Vivo Vein Graft Engineering via Transfection IV (PREVENT IV) trial undergoing protocol-mandated follow-up angiography 12 to 18 months post-coronary artery bypass grafting or earlier clinically driven angiography. Outcomes included patient- and graft-level angiographic VGF (≥75% stenosis or occlusion). Variables were selected by using Fast False Selection Rate methodology. We examined relationships between variables and VGF in patient- and graft-level models by using logistic regression without and with generalized estimating equations. At 12

SUBMITTER: Hess CN 

PROVIDER: S-EPMC4206593 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature