Analytic power and sample size calculation for the genotypic transmission/disequilibrium test in case-parent trio studies.

ABSTRACT: Case-parent trio studies considering genotype data from children affected by a disease and their parents are frequently used to detect single nucleotide polymorphisms (SNPs) associated with disease. The most popular statistical tests for this study design are transmission/disequilibrium tests (TDTs). Several types of these tests have been developed, for example, procedures based on alleles or genotypes. Therefore, it is of great interest to examine which of these tests have the highest statistical power to detect SNPs associated with disease. Comparisons of the allelic and the genotypic TDT for individual SNPs have so far been conducted based on simulation studies, since the test statistic of the genotypic TDT was determined numerically. Recently, however, it has been shown that this test

SUBMITTER: Neumann C 

PROVIDER: S-EPMC4206700 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature