Fidelity assessment of a clinical practice research datalink conversion to the OMOP common data model.

ABSTRACT:

Background

The unique structure and coding of the Clinical Practice Research Datalink (CPRD) presents challenges for epidemiologic analysis and for comparisons with other databases. To address this limitation we sought to transform CPRD into the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM).

Methods

An extraction, transformation and loading process was developed, which detailed source code mappings, Read code domain classification, an imputation algorithm for drug duration and special handling of lifestyle/clinical data. Completeness and accuracy of the above elements were assessed. A final validation exercise involved replication of a published case-control study that examined use of nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of f

SUBMITTER: Matcho A 

PROVIDER: S-EPMC4206771 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature