Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population.

ABSTRACT:

Aim

To assess the association between age-related macular degeneration (AMD) and three single nucleotide polymorphisms (SNPs) related to the vascular endothelial growth factor (VEGF) gene.

Methods

The patients who were diagnosed with AMD were included in this prospective study. Three SNPs (rs1413711, rs2146323, and rs3025033) of the VEGF gene were genotyped by real-time polymerase chain reaction in the genomic DNA isolated from peripheral blood samples of the 82 patients and 80 controls.

Results

The genotype frequencies of rs1413711 and rs2146323 were not significantly different between the study group and the control group (P=0.072 and P=0.058). However, there was a significant difference in the genotype frequencies of these SNPs between the wet type AMD and dry type

SUBMITTER: Bulgu Y 

PROVIDER: S-EPMC4206879 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature