Modulation of gene expression in guinea pig paraflocculus after induction of hearing loss.

ABSTRACT: Hearing loss often results in plastic changes in the central auditory pathways, which may be involved in the generation of tinnitus, a phantom auditory sensation. However, although animal studies have consistently shown increased neural activity in auditory structures after hearing loss, tinnitus does not always develop. It has therefore been suggested that non-auditory structures perform a gating or regulatory role that determines whether the increased activity in auditory structures leads to conscious perception. Recent evidence points to the paraflocculus of the cerebellum as having such a role. Therefore, we investigated the early effects of hearing loss on gene expression in guinea pig paraflocculus. Gene expression was investigated after two weeks recovery from either acoustic or mec

SUBMITTER: Mulders WH 

PROVIDER: S-EPMC4207248 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature