Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling.

ABSTRACT: Memory consolidation is defined by the stabilization of a memory trace after acquisition, and consists of numerous molecular cascades that mediate synaptic plasticity. Commonly, a distinction is made between an early and a late consolidation phase, in which early refers to the first hours in which labile synaptic changes occur, whereas late consolidation relates to stable and long-lasting synaptic changes induced by de novo protein synthesis. How these phases are linked at a molecular level is not yet clear. Here we studied the interaction of the cyclic nucleotide-mediated pathways during the different phases of memory consolidation in rodents. In addition, the same pathways were studied in a model of neuronal plasticity, long-term potentiation (LTP). We demonstrated that cGMP/protein kina

SUBMITTER: Bollen E 

PROVIDER: S-EPMC4207334 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature