Mangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets.

ABSTRACT: Excessive dietary fat intake causes systemic metabolic toxicity, manifested in weight gain, hyperglycemia, and insulin resistance. In addition, carbohydrate utilization as a fuel is substantially inhibited. Correction or reversal of these effects during high-fat diet (HFD) intake is of exceptional interest in light of widespread occurrence of diet-associated metabolic disorders in global human populations. Here we report that mangiferin (MGF), a natural compound (the predominant constituent of Mangifera indica extract from the plant that produces mango), protected against HFD-induced weight gain, increased aerobic mitochondrial capacity and thermogenesis, and improved glucose and insulin profiles. To obtain mechanistic insight into the basis for these effects, we determined that mice expos

SUBMITTER: Apontes P 

PROVIDER: S-EPMC4207399 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature