Impact of repeated vaccination on vaccine effectiveness against influenza A(H3N2) and B during 8 seasons.

ABSTRACT:

Background

Recent studies suggest that influenza vaccination in the previous season may influence the effectiveness of current-season vaccination, but this has not been assessed in a single population over multiple years.

Methods

Patients presenting with acute respiratory illness were prospectively enrolled during the 2004-2005 through 2012-2013 influenza seasons. Respiratory swabs were tested for influenza and vaccination dates obtained from a validated registry. Vaccination status was determined for the current, previous, and prior 5 seasons. Vaccine effectiveness (VE) was calculated for participants aged ≥9 years using logistic regression models with an interaction term for vaccination history.

Results

There were 7315 enrollments during 8 seasons; 1056 (14%) and 65

SUBMITTER: McLean HQ 

PROVIDER: S-EPMC4207422 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature