Linking macroscopic with microscopic neuroanatomy using synthetic neuronal populations.

ABSTRACT: Dendritic morphology has been shown to have a dramatic impact on neuronal function. However, population features such as the inherent variability in dendritic morphology between cells belonging to the same neuronal type are often overlooked when studying computation in neural networks. While detailed models for morphology and electrophysiology exist for many types of single neurons, the role of detailed single cell morphology in the population has not been studied quantitatively or computationally. Here we use the structural context of the neural tissue in which dendritic trees exist to drive their generation in silico. We synthesize the entire population of dentate gyrus granule cells, the most numerous cell type in the hippocampus, by growing their dendritic trees within their characteri

SUBMITTER: Schneider CJ 

PROVIDER: S-EPMC4207466 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature