Isoflurane suppresses early cortical activity.

ABSTRACT:

Objective

Isoflurane and other volatile anesthetics are widely used in children to induce deep and reversible coma, but they may also exert neurotoxic actions. The effects of volatile anesthetics on the immature brain activity remain elusive, however.

Methods

The effects of isoflurane on spontaneous and sensory-evoked activity were explored using intracortical extracellular field potential and multiple unit recordings in the rat barrel cortex from birth to adulthood.

Results

During the first postnatal week, isoflurane suppressed cortical activity in a concentration-dependent manner. At surgical anesthesia levels (1.5-2%), isoflurane completely suppressed the electroencephalogram and silenced cortical neurons. Although sensory potentials evoked by the principal whisker

SUBMITTER: Sitdikova G 

PROVIDER: S-EPMC4207500 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature