Sex differences in β-adrenergic responsiveness of action potentials and intracellular calcium handling in isolated rabbit hearts.

ABSTRACT: Cardioprotection in females, as observed in the setting of heart failure, has been attributed to sex differences in intracellular calcium handling and its modulation by β-adrenergic signaling. However, further studies examining sex differences in β-adrenergic responsiveness have yielded inconsistent results and have mostly been limited to studies of contractility, ion channel function, or calcium handling alone. Given the close interaction of the action potential (AP) and intracellular calcium transient (CaT) through the process of excitation-contraction coupling, the need for studies exploring the relationship between agonist-induced AP and calcium handling changes in female and male hearts is evident. Thus, the aim of this study was to use optical mapping to examine sex differences in ve

SUBMITTER: Hoeker GS 

PROVIDER: S-EPMC4207827 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature