Projected outcomes using different nodule sizes to define a positive CT lung cancer screening examination.

ABSTRACT: Computed tomography (CT) screening for lung cancer has been associated with a high frequency of false positive results because of the high prevalence of indeterminate but usually benign small pulmonary nodules. The acceptability of reducing false-positive rates and diagnostic evaluations by increasing the nodule size threshold for a positive screen depends on the projected balance between benefits and risks. We examined data from the National Lung Screening Trial (NLST) to estimate screening CT performance and outcomes for scans with nodules above the 4mm NLST threshold used to classify a CT screen as positive. Outcomes assessed included screening results, subsequent diagnostic tests performed, lung cancer histology and stage distribution, and lung cancer mortality. Sensitivity, specificit

SUBMITTER: Gierada DS 

PROVIDER: S-EPMC4207860 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature