Monocyte-activation phenotypes are associated with biomarkers of inflammation and coagulation in chronic HIV infection.

ABSTRACT:

Background

Soluble biomarkers of inflammation predict non-AIDS related morbidity and mortality among human immunodeficiency virus (HIV)-infected persons. Exploring associations between plasma biomarkers and cellular phenotypes may identify sources of excess inflammation.

Methods

Plasma biomarkers (interleukin 6 [IL-6] level, D-dimer level, high-sensitivity C-reactive protein [hsCRP] level, soluble CD14 [sCD14] level, and soluble CD163 [sCD163] level) were measured from cryopreserved samples from the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study). We performed immunophenotyping of peripheral blood mononuclear cells for markers of T-cell and monocyte activation, maturation, and migration. We evaluated associations between cellul

SUBMITTER: Wilson EM 

PROVIDER: S-EPMC4207864 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature