How low should you go? Determining the optimal cutoff for exhaled carbon monoxide to confirm smoking abstinence when using cotinine as reference.

ABSTRACT:

Introduction

Confirming abstinence during smoking cessation clinical trials is critical for determining treatment effectiveness. Several biological methods exist for verifying abstinence (e.g., exhaled carbon monoxide [CO], cotinine), and while cotinine provides a longer window of detection, it is not easily used in trials involving nicotine replacement therapy. The Society for Research on Nicotine and Tobacco's Subcommittee on Biochemical Verification cite 8-10 parts per million (ppm) for CO as a viable cutoff to determine abstinence; however, recent literature suggests this cutoff is likely too high and may overestimate the efficacy of treatment.

Methods

This study examined the relationship between CO and cotinine in a sample of 662 individuals participating in a smoking c

SUBMITTER: Cropsey KL 

PROVIDER: S-EPMC4207872 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature