Elevated circulating Sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations.

ABSTRACT:

Context

The role and importance of circulating sclerostin is poorly understood. High bone mass (HBM) caused by activating LRP5 mutations has been reported to be associated with increased plasma sclerostin concentrations; whether the same applies to HBM due to other causes is unknown.

Objective

Our objective was to determine circulating sclerostin concentrations in HBM.

Design and participants

In this case-control study, 406 HBM index cases were identified by screening dual-energy x-ray absorptiometry (DXA) databases from 4 United Kingdom centers (n = 219 088), excluding significant osteoarthritis/artifact. Controls comprised unaffected relatives and spouses.

Main measures

Plasma sclerostin; lumbar spine L1, total hip, and total body DXA; and radial and tibial p

SUBMITTER: Gregson CL 

PROVIDER: S-EPMC4207929 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature