Ontology highlight
ABSTRACT:
SUBMITTER: Ehninger D
PROVIDER: S-EPMC4207939 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Ehninger Dan D Neff Frauke F Xie Kan K
Cellular and molecular life sciences : CMLS 20141101 22
The federal drug administration (FDA)-approved compound rapamycin was the first pharmacological agent shown to extend maximal lifespan in both genders in a mammalian species. A major question then is whether the drug slows mammalian aging or if it has isolated effects on longevity by suppressing cancers, the main cause of death in many mouse strains. Here, we review what is currently known about the effects that pharmacological or genetic mammalian target of rapamycin (mTOR) inhibition have on m ...[more]