Complement cascade and kidney transplantation: The rediscovery of an ancient enemy.

ABSTRACT: The identification of complement activity in serum and immunohistochemical samples represents a core element of nephropathology. On the basis of this observation, different experimental models and molecular studies have shown the role of this cascade in glomerular disease etiology, but the absence of inhibiting drugs have limited its importance. Since 2006, the availability of target-therapies re-defined this ancient pathway, and its blockage, as the new challenging frontier in renal disease treatment. In the graft, the complement cascade is able to initiate and propagate the damage in ischemia-reperfusion injury, C3 glomerulopathy, acute and chronic rejection, atypical hemolytic uremic syndrome and, probably, in many other conditions. The importance of complement-focused research is revea

SUBMITTER: Mella A 

PROVIDER: S-EPMC4208079 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature