Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia.

ABSTRACT:

Context

Chondroitin sulfate proteoglycans (CSPGs), a main component of the brain extracellular matrix, regulate developmental and adult neural functions that are highly relevant to the pathogenesis of schizophrenia. Such functions, together with marked expression of CSPGs in astrocytes within the normal human amygdala and evidence of a disruption of astrocytic functions in this disease, point to involvement of CSPG-glial interactions in schizophrenia.

Hypothesis

Chondroitin sulfate proteoglycan-related abnormalities involve glial cells and extracellular matrix pericellular aggregates (perineuronal nets) in the amygdala and entorhinal cortex of subjects with schizophrenia.

Design

Postmortem case-control study.

Setting

The Translational Neuroscience Laboratory at

SUBMITTER: Pantazopoulos H 

PROVIDER: S-EPMC4208310 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature