A role for the age-dependent loss of α(E)-catenin in regulation of N-cadherin expression and cell migration.

ABSTRACT: The aging kidney has a decreased ability to repair following acute kidney injury. Previous studies from our laboratory have demonstrated a loss in α-catenin expression in the aging rat kidney. We hypothesize that loss of α-catenin expression in tubular epithelial cells may induce changes that result in a decreased repair capacity. In these studies, we demonstrate that decreased α-catenin protein expression is detectable as early as 20 months of age in male Fischer 344 rats. Protein loss is also observed in aged nonhuman primate kidneys, suggesting that this is not a species-specific response. In an effort to elucidate alterations due to the loss of α-catenin, we generated NRK-52E cell lines with stable knockdown of α(E)-catenin (C2 cells). Interestingly, C2 cells had decreased expression o

SUBMITTER: Nichols LA 

PROVIDER: S-EPMC4208646 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature