GRIK4 polymorphism and its association with antidepressant response in depressed patients: a meta-analysis.

ABSTRACT:

Aim

This study aimed to evaluate the relationship between a human GRIK4 gene polymorphism (rs1954787) and responsiveness to antidepressant treatment in depressed patients.

Methods

A meta-analysis was carried out on five studies. Pooled odds ratios (ORs), 95% CIs and a χ(2) test measuring heterogeneity were calculated. A test of publication bias was also conducted.

Results

Alleles and genotypes from a total of 2169 depressed patients were analyzed. The results showed that the C allele appeared more frequently than the T allele in responders to treatment (OR: 1.22; 95% CI: 1.035-1.445; z = 2.36; p = 0.018). Similarly, CC homozygotes were more likely than TT homozygotes to respond to treatment (OR: 1.45; 95% CI: 1.107-1.913; z = 2.69; p = 0.007). No evidence of publicati

SUBMITTER: Kawaguchi DM 

PROVIDER: S-EPMC4208722 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature