A systematic review of bone mineral density and fractures in phenylketonuria.

ABSTRACT:

Introduction

Our objective was to systematically review and analyze published data on bone mineral density (BMD) and fracture rates in patients with phenylketonuria (PKU), and relationships between BMD and phenylalanine levels.

Methodology

We searched PubMed, CINAHL, and Cochrane databases from January 1966 to November 2013 for studies of spine BMD or fracture in PKU and control subjects. We excluded studies assessing skeletal health by ultrasound or peripheral quantitative computer tomography. Both authors reviewed abstracts for inclusion, and read full text papers to extract data.

Results

Sixteen studies met eligibility criteria. Meta-analysis of three studies found that spine BMD was 0.100 g/cm(2) lower (95% CI, -0.110, -0.090 g/cm(2)) in 67 subjects with PKU, comp

SUBMITTER: Hansen KE 

PROVIDER: S-EPMC4208974 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature