Pharmacologic sex hormones in pregnancy in relation to offspring obesity.

ABSTRACT:

Objective

To assess the association between in utero exposure to either diethylstilbestrol (DES) or an oral contraceptive in pregnancy and offspring obesity.

Methods

Using data from the Collaborative Perinatal Project (1959-1974), a multicenter prospective study of pregnant women and their offspring, we examined overweight or obesity among 34,419 children with height and weight data at age 7 years. Generalized linear models to estimate the adjusted odds ratio (aOR) for overweight or obesity (≥85th percentile) or obesity (≥95th percentile) in the offspring according to exposure during different months of pregnancy were used.

Results

Oral contraceptive use during pregnancy was positively associated with offspring overweight or obesity and obesity. The magnitude of assoc

SUBMITTER: Jensen ET 

PROVIDER: S-EPMC4209008 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature