Preservation of neurocognitive function and local control of 1 to 3 brain metastases treated with surgery and carmustine wafers.

ABSTRACT:

Background

Neurosurgical resection and whole-brain radiation therapy (WBRT) are accepted treatments for single and oligometastatic cancer to the brain. To avoid the decline in neurocognitive function (NCF) linked to WBRT, the authors conducted a prospective, multicenter, phase 2 study to determine whether surgery and carmustine wafers (CW), while deferring WBRT, could preserve NCF and achieve local control (LC).

Methods

NCF and LC were measured in 59 patients who underwent resection and received CW for a single (83%) or dominant (oligometastatic, 2 to 3 lesions) metastasis and received stereotactic radiosurgery (SRS) for tiny nodules not treated with resection plus CW. Preservation of NCF was defined as an improvement or a decline ≤ 1 standard deviation from baseline in 3 do

SUBMITTER: Brem S 

PROVIDER: S-EPMC4209121 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature