Ulinastatin activates haem oxygenase 1 antioxidant pathway and attenuates allergic inflammation.

ABSTRACT:

Background and purpose

Ulinastatin (UTI), a serine protease inhibitor, was recently found to have an anti-inflammatory action. However, the mechanisms mediating this anti-inflammatory effect are not well understood. This study tested the hypothesis that UTI suppresses allergic inflammation by inducing the expression of haem oxygenase 1 (HO1).

Experimental approach

Control mice and mice sensitized (on days 1, 9 and 14) and challenged (on days 21 to 27) with ovalbumin (OVA) were treated with UTI. The effects of UTI on basal expression of HO1 and that induced by OVA challenge were examined. The involvement of UTI-induced HO1 expression in anti-inflammatory and antioxidant effects of UTI was also evaluated.

Key results

UTI markedly increased basal HO1 protein expression i

SUBMITTER: Song D 

PROVIDER: S-EPMC4209147 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature