A marginal benefit approach for vaccinating influenza "superspreaders".

ABSTRACT:

Background

There is widespread recognition that interventions targeting "superspreaders" are more effective at containing epidemics than strategies aimed at the broader

Population

However, little attention has been devoted to determining optimal levels of coverage for targeted vaccination strategies, given the nonlinear relationship between program scale and the costs and benefits of identifying and successfully administering vaccination to potential superspreaders.

Methods

We developed a framework for such an assessment derived from a transmission model of seasonal influenza parameterized to emulate typical seasonal influenza epidemics in the US. We used this framework to estimate how the marginal benefit of expanded targeted vaccination changes with the proportion o

SUBMITTER: Skene KJ 

PROVIDER: S-EPMC4209160 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature