Incidence of hypercalciuria and hypercalcemia during vitamin D and calcium supplementation in older women.

ABSTRACT:

Objective

This study aims to prospectively assess the incidence of hypercalciuria and hypercalcemia with different doses of vitamin D and with a calcium intake of approximately 1,200 mg/day.

Methods

This was a 1-year randomized placebo-controlled study of vitamin D (400-4,800 IU/d) in 163 white women aged 57 to 90 years. Calcium citrate tablets (200 mg) were added to the diet to achieve a total calcium intake of approximately 1,200 mg/day in all groups. All women had vitamin D insufficiency at baseline, with serum 25-hydroxyvitaminD levels lower than 20 ng/mL (50 nmol/L). Serum and 24-hour urine calcium were collected every 3 months on supplementation, any test result above the upper reference range represented an episode of hypercalcemia or hypercalciuria. Mixed-effects mod

SUBMITTER: Gallagher JC 

PROVIDER: S-EPMC4209182 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature