A Hox regulatory network of hindbrain segmentation is conserved to the base of vertebrates.

ABSTRACT: A defining feature governing head patterning of jawed vertebrates is a highly conserved gene regulatory network that integrates hindbrain segmentation with segmentally restricted domains of Hox gene expression. Although non-vertebrate chordates display nested domains of axial Hox expression, they lack hindbrain segmentation. The sea lamprey, a jawless fish, can provide unique insights into vertebrate origins owing to its phylogenetic position at the base of the vertebrate tree. It has been suggested that lamprey may represent an intermediate state where nested Hox expression has not been coupled to the process of hindbrain segmentation. However, little is known about the regulatory network underlying Hox expression in lamprey or its relationship to hindbrain segmentation. Here, using a nov

SUBMITTER: Parker HJ 

PROVIDER: S-EPMC4209185 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature