Ontology highlight
ABSTRACT:
SUBMITTER: Wong IY
PROVIDER: S-EPMC4209198 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Nature materials 20140817 11
During cancer progression, malignant cells in the tumour invade surrounding tissues. This transformation of adherent cells to a motile phenotype has been associated with the epithelial-mesenchymal transition (EMT). Here, we show that EMT-activated cells migrate through micropillar arrays as a collectively advancing front that scatters individual cells. Individual cells with few neighbours dispersed with fast, straight trajectories, whereas cells that encountered many neighbours migrated collecti ...[more]