Cardiovascular event risk dynamics over time in older patients on dialysis: a generalized multiple-index varying coefficient model approach.

ABSTRACT: Among patients on dialysis, cardiovascular disease and infection are leading causes of hospitalization and death. Although recent studies have found that the risk of cardiovascular events is higher after an infection-related hospitalization, studies have not fully elucidated how the risk of cardiovascular events changes over time for patients on dialysis. In this work, we characterize the dynamics of cardiovascular event risk trajectories for patients on dialysis while conditioning on survival status via multiple time indices: (1) time since the start of dialysis, (2) time since the pivotal initial infection-related hospitalization, and (3) the patient's age at the start of dialysis. This is achieved by using a new class of generalized multiple-index varying coefficient (GM-IVC) models. Th

SUBMITTER: Estes JP 

PROVIDER: S-EPMC4209204 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature