Protein carbamylation in kidney disease: pathogenesis and clinical implications.

ABSTRACT: Carbamylation describes a nonenzymatic posttranslational protein modification mediated by cyanate, a dissociation product of urea. When kidney function declines and urea accumulates, the burden of carbamylation naturally increases. Free amino acids may protect proteins from carbamylation, and protein carbamylation has been shown to increase in uremic patients with amino acid deficiencies. Carbamylation reactions are capable of altering the structure and functional properties of certain proteins and have been implicated directly in the underlying mechanisms of various disease conditions. A broad range of studies has demonstrated how the irreversible binding of urea-derived cyanate to proteins in the human body causes inappropriate cellular responses leading to adverse outcomes such as accel

SUBMITTER: Kalim S 

PROVIDER: S-EPMC4209336 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature