Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers.

ABSTRACT:

Background

Efavirenz exhibits multiple interactions with drug-metabolizing enzymes and transporters, and for this reason efavirenz-based HIV therapy is associated with altered pharmacokinetics of coadministered drugs. Probably by the same mechanism, efavirenz-based HIV therapy affects the disposition of endogenous compounds, but this effect is difficult to directly link with efavirenz because it is used in combination with other drugs.

Objectives

To explore the effect of efavirenz monotherapy on biochemical laboratory values in a clinical trial of healthy volunteers.

Methods

Men and women (aged 18-49 years) with body mass index ≤32 who were assessed to be healthy based on medical history, physical examination, and standard laboratory screening received a single (600 m

SUBMITTER: Metzger IF 

PROVIDER: S-EPMC4209507 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature