BRCA1 Gene Mutations in Breast Cancer Patients from Kerman Province, Iran.

ABSTRACT:

Background

Breast cancer is the most common malignancy in Iranian women. Mutations in BRCA1 gene is one of the important genetic predisposing factors in breast cancer. This gene is a tumor suppressor that plays an important role in regulating the functions of RAD51 protein for strand invasion in homologous recombination repair.

Methods

The BRCA1 gene has amplified in the DNA isolated from breast cancer patients' leukocytes, using Polymerase Chain Reaction technique. The PCR products have sequenced using an automated DNA sequencer and subsequently obtained data have aligned with the human BRCA1 DNA sequences available online.

Results

In this study, we have considered nine different mutations on 60 examined chromosomes from 30 patients, living in Kerman province. A dele

SUBMITTER: Saleh-Gohari N 

PROVIDER: S-EPMC4209574 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature