Default mode network mechanisms of transcranial magnetic stimulation in depression.

ABSTRACT:

Background

Repetitive transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex (DLPFC) is an established treatment for depression, but its underlying mechanism of action remains unknown. Abnormalities in two large-scale neuronal networks-the frontoparietal central executive network (CEN) and the medial prefrontal-medial parietal default mode network (DMN)-are consistent findings in depression and potential therapeutic targets for TMS. Here, we assessed the impact of TMS on activity in these networks and their relation to treatment response.

Methods

We used resting state functional magnetic resonance imaging to measure functional connectivity within and between the DMN and CEN in 17 depressed patients, before and after a 5-week course of TMS. Motivated by

SUBMITTER: Liston C 

PROVIDER: S-EPMC4209727 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature