Serum phosphorus levels and pill burden are inversely associated with adherence in patients on hemodialysis.

ABSTRACT:

Background

Phosphate binders (PBs) account for about one half of the daily pill burden for US hemodialysis (HD) patients, which may reduce adherence. Adherence can be estimated by the medication possession ratio (MPR), which is defined as the proportion of time a patient had sufficient medication to have taken it as prescribed. Gaps of time between prescription fills lower the patient's MPR. We assessed the association of PB pill burden and adherence (MPR) with phosphorus goal attainment.

Methods

Using pharmacy management program data, HD patients on PB monotherapy were tracked from first PB fill during 1 January 2007-30 June 2011 for 1 year, or until PB change or censoring. Data were assessed with generalized linear models.

Results

We analyzed 8616 patients. Higher p

SUBMITTER: Wang S 

PROVIDER: S-EPMC4209875 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature