The association between glomerular filtration rate and left ventricular function in two independent community-based cohorts of elderly.

ABSTRACT:

Background

The cardiorenal syndrome, the detrimental bi-directional interplay between symptomatic heart failure and chronic kidney disease, is a major clinical challenge. Nonetheless, it is unknown if this interplay begins already at an asymptomatic stage. Therefore we investigated whether the glomerular filtration rate (GFR) is associated with left ventricular function in participants free from clinical heart failure and with a left ventricular ejection fraction (LVEF) >40% and with pre-specified sub-group analyses in individuals with a GFR >60 mL/min/m(2).

Methods

Two independent community-based cohorts were used; the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; n = 911; 50% women; mean age: 70 years) and the Uppsala Longitudinal Study of Adult M

SUBMITTER: Nerpin E 

PROVIDER: S-EPMC4209878 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature