Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers.

ABSTRACT:

Background

Acute kidney injury (AKI) remains a deadly condition. Tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein (IGFBP)7 are two recently discovered urinary biomarkers for AKI. We now report on the development, and diagnostic accuracy of two clinical cutoffs for a test using these markers.

Methods

We derived cutoffs based on sensitivity and specificity for prediction of Kidney Disease: Improving Global Outcomes Stages 2-3 AKI within 12 h using data from a previously published multicenter cohort (Sapphire). Next, we verified these cutoffs in a new study (Opal) enrolling 154 critically ill adults from six sites in the USA.

Results

One hundred subjects (14%) in Sapphire and 27 (18%) in Opal met the primary end point. The re

SUBMITTER: Hoste EA 

PROVIDER: S-EPMC4209880 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature