Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans.

ABSTRACT: Recent models of episodic memory propose a division of labor among medial temporal lobe cortices comprising the parahippocampal gyrus. Specifically, perirhinal and lateral entorhinal cortices are thought to comprise an object/item information pathway, whereas parahippocampal and medial entorhinal cortices are thought to comprise a spatial/contextual information pathway. Although several studies in human subjects have demonstrated a perirhinal/parahippocampal division, such a division among subregions of the human entorhinal cortex has been elusive. Other recent work has implicated pattern separation computations in the dentate gyrus and CA3 subregions of the hippocampus as a mechanism supporting the resolution of mnemonic interference. However, the nature of contributions of medial tempora

SUBMITTER: Reagh ZM 

PROVIDER: S-EPMC4210036 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature