Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process.

ABSTRACT: How malignant gliomas arise in a mature brain remains a mystery, hindering the development of preventive and therapeutic interventions. We previously showed that oligodendrocyte precursor cells (OPCs) can be transformed into glioma when mutations are introduced perinatally. However, adult OPCs rarely proliferate compared with their perinatal counterparts. Whether these relatively quiescent cells have the potential to transform is unknown, which is a critical question considering the late onset of human glioma. Additionally, the premalignant events taking place between initial mutation and a fully developed tumor mass are particularly poorly understood in glioma. Here we used a temporally controllable Cre transgene to delete p53 and NF1 specifically in adult OPCs and demonstrated that these

SUBMITTER: Galvao RP 

PROVIDER: S-EPMC4210043 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature