Factors associated with beta-cell dysfunction in type 2 diabetes: the BETADECLINE study.

ABSTRACT:

Aims

Beta-cell dysfunction is an early event in the natural history of type 2 diabetes. However, its progression is variable and potentially influenced by several clinical factors. We report the baseline data of the BetaDecline study, an Italian prospective multicenter study on clinical predictors of beta-cell dysfunction in type 2 diabetes.

Materials and methods

Clinical, lifestyle, and laboratory data, including circulating levels of inflammatory markers and non-esterified fatty acids, were collected in 507 type 2 diabetic outpatients on stable treatment with oral hypoglycemic drugs or diet for more than 1 year. Beta-cell dysfunction was evaluated by calculating the proinsulin/insulin ratio (P/I).

Results

At baseline, the subjects in the upper PI/I ratio quartile we

SUBMITTER: Russo GT 

PROVIDER: S-EPMC4210056 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature