The effect of S-adenosylmethionine on cognitive performance in mice: an animal model meta-analysis.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most frequently diagnosed form of dementia resulting in cognitive impairment. Many AD mouse studies, using the methyl donor S-adenosylmethionine (SAM), report improved cognitive ability, but conflicting results between and within studies currently exist. To address this, we conducted a meta-analysis to evaluate the effect of SAM on cognitive ability as measured by Y maze performance. As supporting evidence, we include further discussion of improvements in cognitive ability, by SAM, as measured by the Morris water maze (MWM).

Methods

We conducted a comprehensive literature review up to April 2014 based on searches querying MEDLINE, EMBASE, Web of Science, the Cochrane Library and Proquest Theses and Dissertation databases. We identif

SUBMITTER: Montgomery SE 

PROVIDER: S-EPMC4210123 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature