Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis.

ABSTRACT: Distinguishing tumor from normal glandular breast tissue is an important step in breast-conserving surgery. Because this distinction can be challenging in the operative setting, up to 40% of patients require an additional operation when traditional approaches are used. Here, we present a proof-of-concept study to determine the feasibility of using desorption electrospray ionization mass spectrometry imaging (DESI-MSI) for identifying and differentiating tumor from normal breast tissue. We show that tumor margins can be identified using the spatial distributions and varying intensities of different lipids. Several fatty acids, including oleic acid, were more abundant in the cancerous tissue than in normal tissues. The cancer margins delineated by the molecular images from DESI-MSI were cons

SUBMITTER: Calligaris D 

PROVIDER: S-EPMC4210338 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature