Detection of atypical genes in virus families using a one-class SVM.

ABSTRACT:

Background

The diversity of viruses, the absence of universally common genes in them, and their ability to act as carriers of genetic material make assessment of evolutionary paths of viral genes very difficult. One important factor contributing to this complexity is horizontal gene transfer.

Results

We explore the possibility for the systematic identification of atypical genes within virus families, including viruses whose genome is not encoded by a double-stranded DNA. Our method is based on gene statistical features that differ in genes that were subject of recent horizontal gene transfer from those of the genome in which they are observed. We employ a one-class SVM approach to detect atypical genes within a virus family basing of their statistical signatures and without

SUBMITTER: Metzler S 

PROVIDER: S-EPMC4210486 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature