Staphylococcus aureus ST398 gene expression profiling during ex vivo colonization of porcine nasal epithelium.

ABSTRACT:

Background

Staphylococcus aureus is a common human and animal opportunistic pathogen. In humans nasal carriage of S. aureus is a risk factor for various infections. Methicillin-resistant S. aureus ST398 is highly prevalent in pigs in Europe and North America. The mechanism of successful pig colonization by MRSA ST398 is poorly understood. Previously, we developed a nasal colonization model of porcine nasal mucosa explants to identify molecular traits involved in nasal MRSA colonization of pigs.

Results

We report the analysis of changes in the transcription of MRSA ST398 strain S0462 during colonization on the explant epithelium. Major regulated genes were encoding metabolic processes and regulation of these genes may represent metabolic adaptation to nasal mucosa explants. C

SUBMITTER: Tulinski P 

PROVIDER: S-EPMC4210494 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature