HilA-like regulators in Escherichia coli pathotypes: the YgeH protein from the enteroaggregative strain 042.

ABSTRACT:

Background

The HilA protein is the master regulator of the Salmonella pathogenicity island 1 (SPI1). EilA and YgeH proteins show a moderate similarity to HilA and are encoded in pathogenicity islands from several E. coli strains, both pathogenic and non-pathogenic. In the present work we characterize the YgeH protein from the enteroaggregative E. coli strain 042 (locus tag EC042_3050).

Results

We show that both E. coli 042 YgeH and EilA proteins are able to functionally replace HilA in Salmonella. Interestingly, this is not the rule for all YgeH proteins: the YgeH protein from the enterohaemorragic E. coli strain O157 appears to be non-functional. ygeH expression is not influenced by growth osmolarity or temperature, and moderately increases in cells entering the stationary

SUBMITTER: Huttener M 

PROVIDER: S-EPMC4210603 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature