Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease.

ABSTRACT:

Objective

Genome-wide association studies have identified several genetic variants associated with coronary heart disease (CHD). The aim of this study was to evaluate the genetic risk discrimination and reclassification and apply the results for a 2-stage population risk screening strategy for CHD.

Approach and results

We genotyped 28 genetic variants in 24 124 participants in 4 Finnish population-based, prospective cohorts (recruitment years 1992-2002). We constructed a multilocus genetic risk score and evaluated its association with incident cardiovascular disease events. During the median follow-up time of 12 years (interquartile range 8.75-15.25 years), we observed 1093 CHD, 1552 cardiovascular disease, and 731 acute coronary syndrome events. Adding genetic information t

SUBMITTER: Tikkanen E 

PROVIDER: S-EPMC4210840 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature